Hypothermic perfusion has given the longest storage time for canine kidneys with the best result being 8 day storage. This experimental model used a storage temperature of 8°C and a Plasma Protein Fraction (PPF) based perfusate. The octanoic acid content of PPF was found to influence the results of preservation in five-day storage. Both octanoic acid and oleic acid stimulated oxygen consumption to a similar degree during hypothermic perfusion suggesting that the detrimental effect of Octanoic acid was due to direct metabolic stimulation rather than uncoupling of oxidatative phosphorylation.
^Wight J, Chilcott J, Holmes M, Brewer N (2003). "The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors". Health Technol Assess7 (25): 1–94. PMID14499050.