Macroangiopathy

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It has been suggested that this article be merged into Atherosclerosis. (Discuss) Proposed since February 2012.

Macroangiopathy is an angiopathy of the greater blood vessels.^[1]

Pathophysiology [edit]

In macroangiopathy, fat and blood clots build up in the large blood vessels, stick to the vessel walls, and block the flow of blood.

The decrease of blood flow through stenosis or clot formation impair the flow of oxygen and nutrients to cells further down the bloodstream (called ischemia) and lead to their death (necrosis and gangrene, which in turn may require amputation). Plasma homocysteine level could be one of the number of independent risk factor for macroangiopathy in patients with diabetes mellitus and they can be reduced by parental treatment with mecobalamine(Neuromet by Merck).

Related conditions [edit]

Macroangiopathy, may cause other complications, such as ischemic heart disease, stroke and peripheral vascular disease which contributes to the diabetic foot ulcers and the risk of amputation.

(Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). The best known and most prevalent angiopathy is the diabetic angiopathy, a complication that may occur in chronic diabetes.

There are two types of angiopathy: macroangiopathy and microangiopathy.

References [edit]

^ "Macroangiopathy" at Dorland's Medical Dictionary

Cardiovascular disease: vascular disease · Circulatory system pathology (I70–I99, 440–456)

Arteries, arterioles
and capillaries

Inflammation

Arteritis (Aortitis) · Buerger's disease

Arterial occlusive disease/
peripheral vascular disease

Arteriosclerosis	Atherosclerosis (Foam cell, Fatty streak, Atheroma, Intermittent claudication) · Monckeberg's arteriosclerosis · Arteriolosclerosis (Hyaline, Hyperplastic, oxycholesterol, cholesterol, LDL, trans fat)

Stenosis	Renal artery stenosis · Carotid artery stenosis

Other	Fibromuscular dysplasia · Degos disease · Aortoiliac occlusive disease · Raynaud's phenomenon/Raynaud's disease · Erythromelalgia

Aneurysm/dissection/
pseudoaneurysm

torso: Aortic aneurysm (Thoracic aortic aneurysm, Abdominal aortic aneurysm) · Aortic dissection · Coronary artery aneurysm

head/neck: Cerebral aneurysm · Intracranial berry aneurysm · Carotid artery dissection · Vertebral artery dissection · Familial aortic dissection

Vascular malformation

Arteriovenous malformation · Arteriovenous fistula · Telangiectasia (Hereditary hemorrhagic telangiectasia)

Vascular nevus

Spider angioma · Halo nevus · Cherry hemangioma

Veins

Inflammation	Phlebitis

Venous thrombosis/ Thrombophlebitis	primarily lower limb (Deep vein thrombosis) abdomen (Hepatic veno-occlusive disease, Budd–Chiari syndrome, May-Thurner syndrome, Portal vein thrombosis, Renal vein thrombosis) upper limb/torso (Paget-Schroetter disease, Mondor's disease) head (Cerebral venous sinus thrombosis) Post-thrombotic syndrome

Varicose veins	Varicocele · Gastric varices · Portacaval anastomosis (Hemorrhoid, Esophageal varices, Caput medusae)

Other	Superior vena cava syndrome · Inferior vena cava syndrome · Venous ulcer · Chronic venous insufficiency · Chronic cerebrospinal venous insufficiency

Arteries or veins

Vasculitis · Thrombosis · Embolism (Pulmonary embolism, Cholesterol embolism, Paradoxical embolism) · Angiopathy (Macroangiopathy, Microangiopathy)

Blood pressure

Hypertension	Hypertensive heart disease · Hypertensive nephropathy · Essential hypertension · Secondary hypertension (Renovascular hypertension) · Pulmonary hypertension · Malignant hypertension · Benign hypertension · Systolic hypertension · White coat hypertension

Hypotension	Orthostatic hypotension