Macrocytosis

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Macrocytosis
Classification and external resources
ICD-10 D75.8
ICD-9 289.89
DiseasesDB 7688
eMedicine med/1381

Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). The enlarged erythrocytes are called macrocytes or megalocytes (both words have roots meaning "big cell").

Causes[edit]

Most commonly (especially when the increase in size is mild, and just above normal range) the etiology is bone marrow dysplasia secondary to alcohol abuse and Chronic alcoholism Or gastrointestinal causes Gastrointestinal causes of macrocytosis:

Poor absorption of vitamin B12 in the digestive tract can also cause macrocytosis. Examples of gastrointestinal diseases that may cause macrocytosis include:

Celiac disease (severe sensitivity to gluten from wheat and other grains that causes intestinal damage) Crohn’s disease (inflammatory bowel disease that can affect any part of the gastrointestinal tract) (Source healthgrades.com)

Other causes may include:

Complications[edit]

No complications arise from macrocytosis itself and a prognosis will be determined from its etiology.

See also[edit]