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Classification and external resources
ICD-10 D75.8
ICD-9 289.89
DiseasesDB 7688
eMedicine med/1381

Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). The enlarged erythrocytes are called macrocytes or megalocytes (both words have roots meaning "big cell").


Most commonly (especially when the increase in size is mild, and just above normal range) the etiology is bone marrow dysplasia secondary to alcohol abuse and Chronic alcoholism. Other causes may include:


No complications arise from macrocytosis itself and a prognosis will be determined from its etiology.

See also[edit]