Macula of retina
|Macula of retina|
|Human eye cross-sectional view.|
|Gray's||subject #225 1015|
The macula or macula lutea (from Latin macula, "spot" + lutea, "yellow") is an oval-shaped highly pigmented yellow spot near the center of the retina of the human eye. It has a diameter of around 1.5 mm and is often histologically defined as having two or more layers of ganglion cells. Near its center is the fovea, a small pit that contains the largest concentration of cone cells in the eye and is responsible for central, high resolution vision. The macula also contains the parafovea and perifovea.
Because the macula is yellow in color it absorbs excess blue and ultraviolet light that enter the eye, and acts as a natural sunblock (analogous to sunglasses) for this area of the retina. The yellow colour comes from its content of lutein and zeaxanthin, which are yellow xanthophyll carotenoids, derived from the diet. Zeaxanthin predominates at the macula, while lutein predominates elsewhere in the retina. There is some evidence that these carotenoids protect the pigmented region from some types of macular degeneration.
Clinical significance 
Whereas loss of peripheral vision may go unnoticed for some time, damage to the macula will result in loss of central vision, which is usually immediately obvious. The progressive destruction of the macula is a disease known as macular degeneration and can sometimes lead to the creation of a macular hole. Macular holes are rarely caused by trauma, but if a severe blow is delivered it can burst the blood vessels going to the macula, destroying it.
Visual input from the macula occupies a substantial portion of the brain's visual capacity. As a result, some forms of visual field loss can occur without involving the macula; this is termed macular sparing. (For example, visual field testing might demonstrate homonymous hemianopia with macular sparing.)
In the case of Occipitoparital ischemia owing to occlusion of elements of either posterior cerebral artery, patients may display cortical blindness (which, rarely, can involve blindness that the patient denies having, as seen in Anton's Syndrome), yet display sparing of the macula. This selective sparing is due to the collateral circulation offered to macular tracts by the middle cerebral artery. Neurological examination that confirms macular sparing can go far in representing the type of damage mediated by an infarct, in this case, indicating that the caudal visual cortex (which is the principal recipient of macular projections of the optic nerve) has been spared. Further, it indicates that cortical damage rostral to, and including, lateral geniculate nucleus is an unlikely outcome of the infarction, as too much of the lateral geniculate nucleus is, proportionally, devoted to macular-stream processing.
See also 
- Cherry-red spot
- Cystoid macular edema
- Intermediate uveitis
- Macular corneal dystrophy
- Macular degeneration
- Macular edema
- Macular hypoplasia
- Macular pucker
- Barcelona Macula Foundation: Research for Vision
- Helseth,, Erek. "Posterior Cerebral Artery Stroke". Medscape Reference. Medscape. Retrieved 23 October 2011.
- Siegel, Allan; Sapru, Hreday N. (2006). In Betty Sun. Essential Neuroscience (First Revised ed.). Baltimore, Maryland: Lippincott Williams & Wilkins. ISBN [[Special:BookSources/978-0-7813-9121-2|978-0-7813-9121-2[[Category:Articles with invalid ISBNs]]]] Check
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