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MAD1 mitotic arrest deficient-like 1 (yeast)
Protein MAD1L1 PDB 1go4.png
PDB rendering based on 1go4.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAD1L1 ; MAD1; PIG9; TP53I9; TXBP181
External IDs OMIM602686 MGI1341857 HomoloGene74500 GeneCards: MAD1L1 Gene
RNA expression pattern
PBB GE MAD1L1 204857 at tn.png
More reference expression data
Species Human Mouse
Entrez 8379 17120
Ensembl ENSG00000002822 ENSMUSG00000029554
UniProt Q9Y6D9 Q9WTX8
RefSeq (mRNA) NM_001013836 NM_010752
RefSeq (protein) NP_001013858 NP_034882
Location (UCSC) Chr 7:
1.86 – 2.27 Mb
Chr 5:
140.01 – 140.32 Mb
PubMed search [1] [2]

Mitotic spindle assembly checkpoint protein MAD1 is a protein that in humans is encoded by the MAD1L1 gene.[1][2][3]

MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes.

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.[3]


Mad1 has been shown to interact with HDAC1,[4] Histone deacetylase 2[4] and MAD2L1.[5][6][7]

See also[edit]


  1. ^ Jin DY, Kozak CA, Pangilinan F, Spencer F, Green ED, Jeang KT (May 1999). "Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5". Genomics 55 (3): 363–4. doi:10.1006/geno.1998.5654. PMID 10049595. 
  2. ^ Jin DY, Spencer F, Jeang KT (May 1998). "Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1". Cell 93 (1): 81–91. doi:10.1016/S0092-8674(00)81148-4. PMID 9546394. 
  3. ^ a b "Entrez Gene: MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)". 
  4. ^ a b Yoon, Young-Mee; Baek Kwan-Hyuck; Jeong Sook-Jung; Shin Hyun-Jin; Ha Geun-Hyoung; Jeon Ae-Hwa; Hwang Sang-Gu; Chun Jang-Soo; Lee Chang-Woo (September 2004). "WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase". FEBS Lett. (Netherlands) 575 (1-3): 23–9. doi:10.1016/j.febslet.2004.07.089. ISSN 0014-5793. PMID 15388328. 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Sironi, L; Melixetian M; Faretta M; Prosperini E; Helin K; Musacchio A (November 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. (England) 20 (22): 6371–82. doi:10.1093/emboj/20.22.6371. ISSN 0261-4189. PMC 125308. PMID 11707408. 
  7. ^ Murakumo, Y; Roth T; Ishii H; Rasio D; Numata S; Croce C M; Fishel R (February 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. (UNITED STATES) 275 (6): 4391–7. doi:10.1074/jbc.275.6.4391. ISSN 0021-9258. PMID 10660610.