Higgins started up in comedy in 2005 and has written and performed at many festivals and shows. She began her comedy career on national radio station Today FM after auditioning on The Ray D'Arcy Show in February 2004. She failed to win.
In 2005, she took part in the hidden camera show Naked Camera with fellow comedian and friend PJ Gallagher. She landed her own television show, Maeve Higgins' Fancy Vittles, in 2009. Since 2010 she's occasionally been performing with Josie Long and Isy Suttie.