Mafenide

From Wikipedia, the free encyclopedia
  (Redirected from Mafenide acetate)
Jump to: navigation, search
Mafenide
Mafenide.svg
Mafenide ball-and-stick.png
Systematic (IUPAC) name
4-(Aminomethyl)benzenesulfonamide
Clinical data
AHFS/Drugs.com monograph
Legal status
?
Routes Topical
Identifiers
CAS number 138-39-6 N
ATC code D06BA03
PubChem CID 3998
ChemSpider 3858 YesY
UNII 58447S8P4L YesY
KEGG D02351 YesY
ChEMBL CHEMBL419 YesY
Chemical data
Formula C7H10N2O2S 
Mol. mass 186.233 g/mol
 N (what is this?)  (verify)

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.

Uses[edit]

Mafenide is used to treat severe burns.[1][2] It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.[3]

Mechanism of action[edit]

Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.

Adverse reactions[edit]

Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.

Drug interactions[edit]

There are no significant interactions.

Contraindications[edit]

Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.

Dosage[edit]

For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.

References[edit]

  1. ^ Siuda J. F., Cihonski C. D. (1972). "New compounds: carbamate derivatives of mafenide (homosulfanilamide)". J. Pharm. Sci. 61 (11): 1856–1857. doi:10.1002/jps.2600611143. PMID 4652670. 
  2. ^ Haynes B. (1971). "Mafenide acetate in Burn Treatment". New England J. Medic. 284 (23): 1324. doi:10.1056/NEJM197106102842310. PMID 5576444. 
  3. ^ Haik J, Ashkenazy O, Sinai S, et al. (November 2005). "Burn care standards in Israel: lack of consensus". Burns 31 (7): 845–9. doi:10.1016/j.burns.2005.04.012. PMID 15967581. 

External links[edit]