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Skeletal formula
Ball-and-stick model
CAS number 88859-04-5 N
PubChem 104746
ChemSpider 16736958 YesY
MeSH Mafosfamide
Jmol-3D images Image 1
Molecular formula C9H19Cl2N2O5PS2
Molar mass 401.269 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-Hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein.[1]

Several Phase I trials have been completed.[2][3]


  1. ^ Ludeman SM. The chemistry of the metabolites of cyclophosphamide. Curr Pharm Des. 1999 Aug;5(8):627-43. PMID 10469895
  2. ^ "Intrathecal Mafosfamide". U.S. National Institutes of Health. August 21, 2006. Retrieved 2007-07-13. Identifier NCT00062881.
  3. ^ "Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors". U.S. National Institutes of Health. February 20, 2007. Retrieved 2007-07-13. Identifier NCT00031928.