Magaldrate

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Magaldrate
Magaldrate.png
Systematic (IUPAC) name
Magnesium aluminate monohydrate
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a682683
Pregnancy cat. C
Legal status OTC
Routes Oral
Pharmacokinetic data
Bioavailability Negligible
Metabolism Nil
Excretion Fecal and renal
Identifiers
CAS number 1317-26-6 YesY
ATC code A02AD02
A02AF01 (combination with antiflatulents)
PubChem CID 6336542
ChemSpider 4891688 YesY
UNII 6V88E24N5T YesY
Chemical data
Formula AlMg2(OH)7·H2O
Mol. mass 212.66 g/mol
 YesY (what is this?)  (verify)

Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux.

Available forms[edit]

Magaldrate is available in the form of oral suspension or tablets.

Pharmacology[edit]

Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect. [1]

Interactions and adverse reactions[edit]

Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.

Brand names[edit]

The drug is sold with the following brand names: Digecid Plus (Beximco Pharma, Bangladesh), Marlox Plus (Incepta pharma Bangladesh), Gastid (SK+F, Bangladesh), Novelta (Bangladesh), Gadral (Italy); Magaltop (Italy); Magralibi (Italy); Mylanta (Australia); Riopan (Argentina, Austria, Brazil, Egypt, Germany, Italy, Mexico, Belgium, Switzerland, Greece).

References[edit]

  1. ^ Laurence L., Brunton. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed.