Sansone started recording her music in 1984. Since then, she has made over a dozen recordings, both solo and as a guest artist or in collaboration with numerous recording artists such as Bonnie Rideout, Al Petteway and Ensemble Galilei.
Although she is perhaps best known for her hammered dulcimer recordings, she also plays the piano, guitar, mandolin, and Northumbrian small-pipes.
Sansone operates her own music label, Maggie's Music. The label features over fifty recordings of Celtic and contemporary acoustic music featuring twelve recording artists that include Al Petteway, Amy White, Bonnie Rideout, Robin Bullock, Karen Ashbrook, Paul Oorts, the City of Washington Pipe Band, Ensemble Galilei, Sue Richards, Hesperus Early Music Ensemble with Tina Chancey and more.