Main-Spessart is a district in Bavaria, Germany. It is bounded by (from the north and clockwise) the districts of Bad Kissingen, Schweinfurt and Würzburg, the state of Baden-Württemberg (district of Main-Tauber), the districts of Miltenberg and Aschaffenburg, and the state of Hesse (district of Main-Kinzig).
The district was established in 1972 by merging the former districts of Gemünden, Karlstadt, Lohr and Marktheidenfeld.
The Main River forms a large horse-shoe bend in the district, entering in the southeast and leaving to the southwest. In the north it is joined by the Franconian Saale River. In the west of the district the Spessart mountains are rising.
Coordinates: 49°55′N 9°45′E / 49.92°N 9.75°E / 49.92; 9.75