Major vault protein

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Major vault protein
Protein MVP PDB 1y7x.png
PDB rendering based on 1y7x.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MVP ; LRP; VAULT1
External IDs OMIM605088 MGI1925638 HomoloGene3752 GeneCards: MVP Gene
RNA expression pattern
PBB GE MVP 202180 s at tn.png
PBB GE MVP gnf1h10986 at tn.png
PBB GE MVP gnf1h10989 at tn.png
More reference expression data
Species Human Mouse
Entrez 9961 78388
Ensembl ENSG00000013364 ENSMUSG00000030681
UniProt Q14764 Q9EQK5
RefSeq (mRNA) NM_001293204 NM_080638
RefSeq (protein) NP_001280133 NP_542369
Location (UCSC) Chr 16:
29.83 – 29.86 Mb
Chr 7:
126.99 – 127.01 Mb
PubMed search [1] [2]

Major vault protein is a protein that in humans is encoded by the MVP gene.[1][2] 78 copies of the protein assemble into the large compartments called vaults, illustrated and discussed in the article on Vault (organelle).

This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[2]


Major vault protein has been shown to interact with Estrogen receptor alpha,[3] PTEN[4] and PARP4.[5][6]


  1. ^ Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ (Dec 1995). "The drug resistance-related protein LRP is the human major vault protein". Nat Med 1 (6): 578–82. doi:10.1038/nm0695-578. PMID 7585126. 
  2. ^ a b "Entrez Gene: MVP major vault protein". 
  3. ^ Abbondanza, C; Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari A M, Moncharmont B, Puca G A (Jun 1998). "Interaction of Vault Particles with Estrogen Receptor in the MCF-7 Breast Cancer Cell". J. Cell Biol. (UNITED STATES) 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. ISSN 0021-9525. PMC 2132791. PMID 9628887. 
  4. ^ Yu, Zhenbao; Fotouhi-Ardakani Nasser, Wu Liangtang, Maoui Meryem, Wang Shenglong, Banville Denis, Shen Shi-Hsiang (Oct 2002). "PTEN associates with the vault particles in HeLa cells". J. Biol. Chem. (United States) 277 (43): 40247–52. doi:10.1074/jbc.M207608200. ISSN 0021-9258. PMID 12177006. 
  5. ^ van Zon, Arend; Mossink Marieke H; Schoester Martijn; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. (United States) 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. ISSN 0006-291X. PMID 11855821. 
  6. ^ Kickhoefer, V A; Siva A C; Kedersha N L; Inman E M; Ruland C; Streuli M; Rome L H (Sep 1999). "The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase". J. Cell Biol. (UNITED STATES) 146 (5): 917–28. doi:10.1083/jcb.146.5.917. ISSN 0021-9525. PMC 2169495. PMID 10477748. 

Further reading[edit]