In 1822 the town was established as a mission station by Samuel Broadbent and Thomas Hodgson of the Wesleyan Missionary Society and the town was laid out in 1907.
Makwasi is a centre for maize, groundnuts, sorghum and milk production
Makwassie is located 14 kilometres (8.7 mi) south of Wolmaransstad and 78 kilometres (48 mi) north-west of Wesselsbron. It was laid out in 1907 and proclaimed in 1910. At first spelt Maquassi, it was standardized as Makwassie in 1937. The first white child in Transvaal was born there, and the first printing undertaken.