The town is located on the main highway between Kampala and Nairobi, approximately 232 kilometres (144 mi), by road, east of Kampala, Uganda's capital and largest city. The coordinates of the town are:00°38′40″N, 34°15′38″E (Latitude:0.644444; Longitude:34.260556).
Malaba, Uganda is a market town, located 6 miles (9.7 km) southeast of the town of Tororo. The railway also crosses the border between Uganda and Kenya at Malaba.
Malaba is a busy crossing point between Uganda and Kenya on their common border. The town of Busia, 46 kilometres (29 mi) to the south of Malaba is also a very busy crossing point between the two countries. In 2005, Malaba, Uganda was the second busiest border crossing between Uganda and Kenya, based on volume of exports and imports. See table below:
Uganda Border Towns' Market Share of Crossborder Trade in 2005