Malaria No More was established in December 2006 by Peter Chernin and Raymond G. Chambers. Entrepreneur and co-founder of Priceline.comScott Case is the vice-chairman at Malaria No More since 2006. The nonprofit organization has a global network of affiliate organizations in other countries such as Canada, the United Kingdom, the Netherlands, and Japan. This allows for the local advocacy to rally public support and work with other grassroots groups such as the Mosquitoes Suck Tour to inspire students to get involved.
Other organizations, such as Malaria No More continue distribution of more broad-based prophylaxis in Africa.
The organization has announced tentative plans to close in 2015, based on the progress which had been made in its mission by 2011.