Malate dehydrogenase 2

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Malate dehydrogenase 2, NAD (mitochondrial)
Protein MDH2 PDB 1mld.png
PDB rendering based on 1mld.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MDH2 ; M-MDH; MDH; MGC:3559; MOR1
External IDs OMIM154100 MGI97050 HomoloGene55938 ChEMBL: 5917 GeneCards: MDH2 Gene
EC number 1.1.1.37
RNA expression pattern
PBB GE MDH2 209036 s at tn.png
PBB GE MDH2 213333 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4191 17448
Ensembl ENSG00000146701 ENSMUSG00000019179
UniProt P40926 P08249
RefSeq (mRNA) NM_005918 NM_008617
RefSeq (protein) NP_005909 NP_032643
Location (UCSC) Chr 7:
75.68 – 75.7 Mb
Chr 5:
135.78 – 135.79 Mb
PubMed search [1] [2]

Malate dehydrogenase 2, NAD (mitochondrial), also known as MDH2, is a protein which in humans is encoded by the MDH2 gene.[1]

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
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TCACycle_WP78 go to article go to article go to article go to article go to HMDB go to article go to article go to article Go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to HMDB go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article
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TCA Cycle edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". 
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". 

See also[edit]

References[edit]

  1. ^ Habets GG, van der Kammen RA, Willemsen V, Balemans M, Wiegant J, Collard JG (1992). "Sublocalization of an invasion-inducing locus and other genes on human chromosome 7". Cytogenet. Cell Genet. 60 (3–4): 200–5. doi:10.1159/000133336. PMID 1505215. 
  2. ^ "Entrez Gene: MDH2 malate dehydrogenase 2, NAD (mitochondrial)".