Familial male-limited precocious puberty

From Wikipedia, the free encyclopedia
  (Redirected from Male-limited precocious puberty)
Jump to: navigation, search
Familial male-limited precocious puberty
Classification and external resources
OMIM 176410

Familial male-limited precocious puberty, often abbreciated as FMPP, also known as familial sexual precocity or gonadotropin-independent testotoxicosis,[1] is a form of gonadotropin-independent precocious puberty in which boys experience early onset and progression of puberty.[2] Signs of puberty can develop as early as an age of 1 year.

The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an autosomal dominant[1] condition with a mutation of the luteinizing hormone (LH) receptor. Treatment is with drugs that suppress gonadal steroidogenesis, such as cyproterone acetate, ketoconazole, spironolactone, and testolactone.[3]

Male-limited precocious puberty has an autosomal dominant pattern of inheritance.

See also[edit]

References[edit]

  1. ^ a b Online 'Mendelian Inheritance in Man' (OMIM) 176410
  2. ^ Traggiai C, Stanhope R (2003). "Disorders of pubertal development". Best Pract Res Clin Obstet Gynaecol 17 (1): 41–56. doi:10.1053/ybeog.2003.0360. PMID 12758225. 
  3. ^ Reiter EO, Norjavaara E (2005). "Testotoxicosis: current viewpoint". Pediatr Endocrinol Rev 3 (2): 77–86. PMID 16361981. 

External links[edit]