Mallory body
In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.[1]
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[edit] Associated conditions
Mallory bodies are classically found in the livers of people suffering from alcoholic liver disease and were once thought to be specific for that.
They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).[2]
They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.[2]
[edit] Appearance
Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate keratin filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62.
[edit] Eponym
It is named for Frank Burr Mallory. [3]. [2]
[edit] See also
- Ballooning degeneration - another histopathologic finding of steatohepatitis.
[edit] Additional images
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Micrograph showing a Mallory body. Original magnification 400X. H&E stain.
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Micrograph showing a Mallory body. Original magnification 200X. H&E stain.
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Liver micrograph showing abundant Mallory bodies, as seen in alcohol abuse.
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Mallory bodies in hepatocellular carcinoma. Trichrome stain.
[edit] References
- ^ "Cell Injury". http://library.med.utah.edu/WebPath/CINJHTML/CINJ033.html.
- ^ a b c Jensen, K; Gluud, C (Oct 1994). "The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey).". Hepatology 20 (4 Pt 1): 1061–77. doi:10.1002/hep.1840200440. PMID 7927209.
- ^ Template:AKADrewParlin
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