Set in 1957 and the present day, the novel, which is a meditation on memory and personal history, solitude and intimacy, tells the story of Samson Greene, a young and popular professor at Columbia University, who is found wandering in the Nevada desert with no memory of his previous life.
The novel was critically acclaimed. Joy Press, writing in the Village Voice, said: "Krauss is a fluent, thoughtful writer who takes on a lot of complex ideas and rarely loses her grip on them... Man Walks Into a Room is a chilling addition to the annals of amnesia lit. It's a novel that grapples with the ephemeral experience of being human and the realization that we create a lifetime of memories that vanish when we do".Gillian Flynn, in a review for Entertainment Weekly, described Krauss's prose as "casually dazzling, as are the ideas she explores through Samson". The novel won praise from Susan Sontag and was a finalist for the Los Angeles Times Book Prize.