Management of dehydration

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To prevent dehydration and electrolyte loss, it is widely recommended a person begin drinking Oral Rehydration Solution (ORS) as soon as possible. This strategy adds modest amounts of sugar and salt to water. There are prepackaged ORS products available. A person can also use home products such as lightly salted soup and/or lightly salted water from the cooking of rice. Supplemental zinc and potassium are also helpful, but ORS should not be delayed in the case that these are not immediately available.[1][2]

The management of dehydration typically involves the use of oral rehydration solution (ORS). Standard home solutions such as salted rice water, salted yogurt drinks, vegetable and chicken soups with salt can be given. Home solutions such as water in which cereal has been cooked, unsalted soup, green coconut water, weak tea (unsweetened), and unsweetened fresh fruit juices can have from half a teaspoon to full teaspoon of salt (from one-and-a-half to three grams) added per liter. Clean plain water can also be one of several fluids given.[1] There are commercial solutions such as Pedialyte, and relief agencies such as UNICEF widely distribute packets of salts and sugar. A WHO publication for physicians recommends a homemade ORS consisting of one liter water with one teaspoon salt (3 grams) and two tablespoons sugar (18 grams) added[1] (approximately the “taste of tears”[3]). Rehydration Project recommends adding the same amount of sugar but only one-half a teaspoon of salt, stating that this more dilute approach is less risky with very little loss of effectiveness.[4] Both agree that drinks with too much sugar or salt can make dehydration worse.[1][4]

Medical uses[edit]

Medium dehydration[edit]

In what the World Health Organization (WHO) terms "some dehydration," the child or adult is restless and irritable, is thirsty, and will drink eagerly.[1]

WHO recommends that if there is vomiting, don’t stop, but do pause for 5–10 minutes and then restart at a slower pace. (Vomiting seldom prevents successful rehydration since most of the fluid is still absorbed. Plus, vomiting usually stops after the first one to four hours of rehydration.) With the older WHO solution, also give some clean water during rehydration. With the newer reduced-osmolarity, more dilute solution, this is not necessary.[1]

Begin to offer food after the initial four-hour rehydration period with children and adults. With infants, continue to breastfeed even during rehydration as long as the infant will breastfeed. Begin zinc supplementation after initial four-hour rehydration to reduce severity and duration of episode. If available, zinc supplementation should be continued for 10 to 14 days. During the initial period of rehydration, the patient should be re-assessed at least every four hours.[1]

The family should be provided with at least two days worth of ORS packets. WHO recommends, in addition to infants continued to be breastfed, that children older than six months be given some food before being sent home, which helps to emphasize to parents the importance of continuing to feed the child during diarrhea.[1]

Severe dehydration[edit]

In severe dehydration, the person may be lethargic or unconscious, drinks poorly, or may not be able to drink.[1]

In malnourished persons, rehydration should be performed relatively slowly by drinking or by nasogastric tube unless the person is also suffering from shock in which case it should be performed quicker. Malnourished patients should receive a modified ORS which has less sodium, more potassium, and modestly more sugar. For patients not malnourished, rehydration should be performed relatively rapidly by means of intravenous (IV) solution. For infants under one year of age, WHO recommends giving, within the first hour, 30 milliliters of Ringer’s Lactate Solution for each kilogram of body weight, and then, within the next five hours, 70 milliliters of Ringer’s Lactate per kilogram of body weight. For children over one year and for adults, WHO recommends, within the first half hour, 30 milliliters of Ringer’s Lactate per kilogram of body weight, and then, within the next two-and-a-half hours, 70 milliliters per kilogram. For example, if a child weighs fifteen kilograms (who is obviously over one year of age), he or she should receive 450 ml of Ringer's Lactate Solution within the first half hour, and then 1,050 ml of Ringer's Lactate within the next two-and-a-half hours. Patients who can drink, even poorly, should be given Oral Rehydration Solution (ORS) by mouth until the IV drip is running. In addition, all patients should start to receive some ORS when they are able to drink without difficulty, which is usually three to four hours for infants and one to two hours for older persons. ORS provides additional base and potassium which may not be adequately supplied by IV fluid. Ideally, patients should be reassessed every fifteen to thirty minutes until a strong radial pulse is present, and thereafter, assessed at least hourly to confirm that hydration is improving. Hopefully, patients will graduate to the medium dehydration or "some" dehydration category and receive continued treatment as above.[1]

Inadequate replacement of potassium losses during diarrhea can lead to potassium depletion and hypokalaemia (low serum potassium) especially in children with malnutrition. This can potentially cause muscle weakness, impaired kidney function, and cardiac arrhythmia. Hypokalaemia is worsened when base is given to treat acidosis without simultaneously providing potassium, as happens in standard IVs including Ringer's Lactate Solution. ORS can help correct potassium deficit, as can giving foods rich in potassium during diarrhea and after it has stopped.[1]

As in above sections, for all patients, supplemental zinc can help to reduce the severity and duration of diarrhea. In addition, supplemental vitamin A is often recommended, particular for children who have diarrhea during or shortly after measles, or in children who are already malnourished, although ideally for all patients.[1]

Contraindications[edit]

Drinks especially high in simple sugars, such as soft drinks and fruit juices, are not recommended as the main source of hydration, or for children under 5 years of age as they may increase diarrhea.[5] Plain water may be used if more specific and effective ORT preparations of hydrational fluids are unavailable or are not palatable.[5] A nasogastric tube can be used in young children to administer fluids if warranted.[6]

Mechanism of action[edit]

Preparation[edit]

Appropriate amounts of supplemental zinc and potassium should be added if available. But the availability of these should not delay rehydration. As WHO points out, the most important thing is to begin preventing dehydration as early as possible.[1] In another example of prompt ORS hopefully preventing dehydration, CDC recommends for the treatment of cholera continuing to give Oral Rehydration Solution during travel to medical treatment.[2]

The approximate amount of oral rehydration solution (ORS) to be given over four hours can be obtained by multiplying 75 milliliters of solution by the child’s weight in kilograms. For example, a child who weighs 15 kilograms should be given approximately 1,125 ml of ORS over four hours. Of course, the exact amount depends on how dehydrated the child is. And in general, let the person drink as much as they wish. The person can drink a little faster at first and then relatively slowly. For babies, a dropper or syringe without the needle may be used. Toddlers under two should be offered a teaspoonful every 1–2 minutes. Older children and adults may take frequent sips.[1]

Procedure[edit]

Vomiting often occurs during the first hour or two of treatment with ORS, especially if a child drinks the solution too quickly, but this seldom prevents successful rehydration since most of the fluid is still absorbed. WHO recommends that if a child vomits, to wait five or ten minutes and then start to give the solution again more slowly.[1]

In children[edit]

WHO recommends a child with diarrhea continue to be fed. Continued feeding speeds the recovery of normal intestinal function. In contrast, children whose food is restricted, have diarrhea of longer duration and recover intestinal function more slowly. A child should also continue to be breastfed.[1] And in the example of the treatment of cholera, CDC also recommends that persons continue to eat and children continue to be breastfed.[2]

If IV treatment is not available at the facility, WHO recommends sending the child to a nearby facility if it can be reached within 30 minutes and providing the mother with ORS to administer to the child during the trip. If another facility is not available, ORS can be given by mouth as the child can drink and/or by nasogastric tube.[1]

WHO states that knowing the levels of serum electrolytes rarely changes the recommended treatment of children with diarrhea and dehydration, and furthermore, that these values are often misinterpreted. Most electrolyte imbalances are adequately treated by ORS. For example, a child who has been given an excess of sugar or salt like that which is in commercial soft drinks, sugared fruit drinks, or over-concentrated infant formula, may develop hypernatraemic dehydration. This occurs when these over-concentrated solutions sit in the gut and draw water from the rest of the body, and the reduced fluids in the body's tissues then have a higher proportion of salt to fluid. Children with serum sodium greater 150 mmol/liter have thirst out of proportion to other signs of dehydration. There is a danger of convulsions which usually occur when serum sodium concentrations are greater than 165 mmol/liter. Less commonly, convulsions can also occur when serum sodium is less than 130 mmol/liter. Treatment with ORS can usually bring serum sodium concentrations back to normal within twenty-four hours.[1]

Children with diarrhea who drink mostly water or overly dilute drinks with too little salt may develop hyponatraemia (serum sodium less than 130 mmol/liter). This is especially common in children with shigellosis and in severely malnourished children with edema. ORS is safe and effective for nearly all children with hyponatraemia, an exception being children with edema for whom ORS provides too much sodium.[1]

References[edit]

  1. ^ a b c d e f g h i j k l m n o p q r s The Treatment Of Diarrhea, A manual for physicians and other senior health workers, World Health Organization, 2005. See “4.2 Treatment Plan A: home therapy to prevent dehydration and malnutrition,” “4.3 Treatment Plan B: oral rehydration therapy for children with some dehydration,” and “4.4 Treatment Plan C: for patients with severe dehydration” on pages 8 to 16 (12 -20 in PDF). See also “8. MANAGEMENT OF DIARRHOEA WITH SEVERE MALNUTRITION” on pages 22-24 (26-30 in PDF) and “ANNEX 2: ORAL AND INTRAVENOUS REHYDRATION SOLUTIONS” on pages 33-37 (37-41 in PDF).
  2. ^ a b c Community Health Worker Training Materials for Cholera Prevention and Control, CDC, slides at back are dated 11/17/2010. Page 7 states " . . . Continue to breastfeed your baby if the baby has watery diarrhea, even when traveling to get treatment. Adults and older children should continue to eat frequently."
  3. ^ A GUIDE ON SAFE FOOD FOR TRAVELLERS, WELCOME TO SOUTH AFRICA, HOST TO THE 2010 FIFA WORLD CUP (bottom left of page 1).
  4. ^ a b Rehydration Project, http://rehydrate.org/Homemade Oral Rehydration Solution Recipe.
  5. ^ a b "Management of acute diarrhoea and vomiting due to gastoenteritis in children under 5". National Institute of Clinical Excellence. April 2009. 
  6. ^ Webb, A; Starr, M (Apr 2005). "Acute gastroenteritis in children.". Australian family physician 34 (4): 227–31. PMID 15861741.