The Manchester Bridge became Pittsburgh's second bridge to span from the Point to the North Shore. Its predecessor, the wooden covered Union Bridge, opened in 1874 and was demolished in 1907 after suffering extensive damage from a major flood that same year. The new bridge was constructed from 1911-1915. and was opened by Mayor Joseph G. Armstrong on August 8, 1915. It carried motorists across the Allegheny River for the next 54 years, then closed on October 17, 1969 when its successor, the Fort Duquesne Bridge (located closer to the Roberto Clemente Bridge) opened that same day as part of the city's Renaissance I redevelopment project. Efforts were made to save the old Manchester Bridge, but it was determined that it had to be removed (along with the adjoining Point Bridge, defunct since 1959 after the opening of the Fort Pitt Bridge) to complete the construction of the new Point State Park. Explosives were used to drop the south side span into the Allegheny River at 18:42 on September 29, 1970. The original attempt 11 hours earlier was unsuccessful when five of the eight charges failed to detonate. Demolition was subcontracted to Controlled Demolition by Dravos and was overseen by John. D Loizeaux. Less than a month later on October 28, the north span was brought down the same way, this time with no problems.
A footing on the north bank of the Allegheny River from the bridge still survives, not far from the south end zone of Heinz Field, and later on cleaned and carved out as the place to house the Fred Rogers statue.