Maneb

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Maneb
Maneb.svg
Identifiers
CAS number 12427-38-2 YesY
MeSH Maneb
Jmol-3D images Image 1
Properties
Molecular formula (C4H6MnN2S4)n
Molar mass 265,31 g·mol−1
Appearance Yellow to brown colored crystalline solid
Density 1.92 g/cm3
Melting point 192 to 204 °C (378 to 399 °F; 465 to 477 K) (decomposes)
Solubility in water 160 mg/L
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Maneb is a foliate fungicide and is a polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand.[1]

Applications[edit]

It can be also used to create a toxin-based animal model of Parkinson's disease, usually in primates.[2]

Maneb interferes with glucocorticoid metabolism by inhibiting the activity of the enzyme 11β-hydroxysteroid dehydrogenase type 2 which converts cortisol to cortisone.[3]

Regulation[edit]

It was included in a biocide ban proposed by the Swedish Chemicals Agency [4] and approved by the European Parliament on January 13, 2009.[5]

References[edit]

  1. ^ Arno H. Reidies "Manganese Compounds" Ullmann's Encyclopedia of Chemical Technology 2007; Wiley-VCH, Weinheim. doi:10.1002/14356007.a16_123
  2. ^ Cicchetti F, Drouin-Ouellet J, Gross RE (September 2009). "Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?". Trends Pharmacol. Sci. 30 (9): 475–83. doi:10.1016/j.tips.2009.06.005. PMID 19729209. 
  3. ^ Atanasov, AG; Tam, S; Röcken, JM; Baker, ME; Odermatt, A (2003). "Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates". Biochemical and biophysical research communications 308 (2): 257–62. doi:10.1016/s0006-291x(03)01359-7. PMID 12901862. 
  4. ^ "Interpretation of criteria for approval of active substances in the proposed EU plant protection regulation". Swedish Chemicals Agency (KemI). 2008-09-23. Retrieved 2009-01-14. 
  5. ^ "MEPs approve pesticides legislation". 2009-01-13. Retrieved 2009-01-14. 

External links[edit]