Mangafodipir

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Mangafodipir
Mangafodipir 3D sticks.png
Mangafodipir.png
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
  • Not to be used
Intravenous infusion
Pharmacokinetic data
Bioavailability NA
Protein binding 27% (manganese)
Negligible (DPDP)
Half-life 20 minutes (manganese)
50 minutes (DPDP)
Excretion Renal and fecal (manganese)
Renal (DPDP)
Identifiers
119797-12-5 N
V08CA05
PubChem CID 3086672
ChemSpider 2343239 YesY
UNII N02W67RKJS YesY
ChEMBL CHEMBL1628235 N
Chemical data
Formula C22H28MnN4O14P2
689.362 g/mol
 N (what is this?)  (verify)

Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. It has two parts, paramagnetic manganese (II) ions and the chelating agent fodipir (dipyridoxyl diphosphate, DPDP). Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue. The manganese shortens the longitudinal relaxation time (T1), making the normal tissue appear brighter in MRIs. This enhanced contrast allows lesions to be more easily identified.

Teslascan was withdrawn from the US market in 2003[1] and the European market in 2012.[2]


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