Mangostin
| Mangostin | |
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3,6,8-Trihydroxy-2-methoxy-1,7- |
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| Identifiers | |
| CAS number | 6147-11-1  |
| PubChem | 5281650 |
| ChemSpider | 4444969 |
| ChEMBL | CHEMBL323197 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C24H26O6 |
| Molar mass | 410.45 g/mol |
| Exact mass | 410.172939 |
| Appearance | Yellow crystalline solid |
| Melting point |
182 °C, 455 K, 360 °F |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.[1] In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis.[2]
The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. The rind of fully ripe fruits contains the xanthonoids gartanin, 8-disoxygartanin and normangostin. A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.
[edit] References
- ^ Jung H, Su B, Keller W, Mehta R, Kinghorn A (2006). "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 54 (6): 2077–82. doi:10.1021/jf052649z. PMID 16536578.
- ^ Shankaranarayan D, Gopalakrishnan C, Kameswaran L. (1979). "Pharmacological profile of mangostin and its derivatives". Arch Int Pharmacodyn Ther. 239 (2): 257–269. PMID 314790.
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