Manuel Elkin Patarroyo
|Manuel Elkin Patarroyo|
|Born||Manuel Elkin Patarroyo
March 11, 1946
Ataco, Tolima, Colombia
|Education||National University of Colombia (MD)
Rockefeller University (Ph.D)
|Known for||Malaria license|
|Institutions||Hospital San Juan de Dios, National University of Colombia|
|Notable prizes||Prince of Asturias Awards (1994)|
Manuel Elkin Patarroyo (born March 11, 1946) is a Colombian pathologist who made the world's first attempt to create a synthetic vaccine for malaria, a disease transmitted by mosquitoes that affects millions of people in tropical and subtropical regions, including parts of the Americas, Asia, and Africa. The vaccine candidate, first developed in 1987, was evaluated in clinical trials carried out by the WHO in Gambia, Tanzania and Thailand, and had mixed results. In 2009, a comprehensive Cochrane review assessed the SPf66 as being not efficacious in Africa and Asia, and as having a low but statistically significant efficacy of 28% in South America. Today, after more than 33 years of research, the SPf66 malaria vaccine is not recommended for prophylaxis of malaria and is listed as "inactive" by the WHO.
- Fundación Príncipe de Asturias. Manuel Elkin Patarroyo (Spanish). Premiados, Investigación Científica y Técnica, 1994.
- Holloway, M. (1996) Profile: Manuel Elkin Patarroyo – The Man Who Would Conquer Malaria, Scientific American 275(6), 52-56.
- - Susan Aldridge, Magic Molecules: How Drugs Work (Cambridge University Press, 1998), p. 89
- - Graves, P. M. and Gelband, H. (2009) Vaccines for preventing malaria (SPf66) (Review), The Cochrane Library 2009, (2), pp.1-38.
- - WHO (2010) Tables of Malaria Vaccine Projects Globally (Updated December 2010), Initiative for Vaccine Research.
- Structural and Immunological Principles Leading to Chemically Synthesized, Multiantigenic, Multistage, Minimal Subunit-Based Vaccine Development, abstract of article in Chemical Reviews, from de American Chemical Society.
- Emerging Rules for Subunit-Based, Multiantigenic, Multistage Chemically Synthesized Vaccines, abstract of article in Accounts of Chemical Research, from the American Chemical Society.
- Toward A New Generation Of Vaccines For Malaria And Other Diseases in 'Science Daily'.
- Race for Malaria Money
- Scientists Herald Malaria Breakthrough
- Guardian Unlimited: Scientist whose dream of beating disease came true
- Tables of Malaria Vaccine Projects