From the late 1990s Franquelo has worked and collaborated with Adam Lowe and engineer Sven Nebel, creating the Factum Arte studio together. Franquelo trained as an electronic engineer, and now produces installations and sculptures often incorporating electronics or computer control.
In 2002, Franquelo and Lowe contributed to a project, supported by the Egyptian Ministry of Culture and the Supreme Council of Antiquities, to laser-scan and replicate the tomb of Seti I in the Valley of the Kings, which was completed in 2010. It is in storage in Madrid, being held jointly by the Factum Arte, University of Basel, and the Friends of the Royal Tombs project. When the political situation in Egypt stabilises, they plan to install the replica in the Valley of Kings for public viewing 
- Galván, Rocío (October 8, 2009). "Manuel Franquelo: 'El mundo del arte es fascista'". El Mundo (Spain). Retrieved July 7, 2010.
- Untitled (1985)
- The Cultural Chorus (1999), 3 platforms with 12 microprocessor-driven electronic circuits which pose random questions from a generated vocabulary and answer in chorus.
- Preacher and the Chorus (1999) as part of Noise.
- Prints at Marlborough Fine Art
- (in Spanish) Interview in "El Mundo" newspaper