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Manuel Kamytzes Komnenos Doukas Angelos (Greek: Μανουήλ Καμύτζης Κομνηνός Δούκας Άγγελος, ca. 1150 – after 1202) was a Byzantine general who was active in the late 12th century AD. He was the son of Constantine Kamytzes and Maria Angelina, who was the granddaughter of the Byzantine emperor Alexios I Komnenos and Irene Doukaina through her mother Theodora. He was therefore a first cousin of the emperors Isaac II Angelos and Alexios III Angelos, and of Michael I Komnenos Doukas, who was to be despot of Epirus.
He led Imperial troops in 1189, when the Third Crusade crossed Byzantine territory. Manuel afterwards fought against a rival Bulgarian leader, Ivanko, and was captured. The emperor took no steps to ransom him. Manuel therefore asked his son-in-law, Dobromir Chrysos, to pay the ransom, and joined him in fighting against the Empire.
Manuel's wife's name is unknown. He is known to have had a daughter, who was forced by the emperor Alexius III Angelus to divorce her husband and marry Dobromir in 1198. He also had a son, named John Kamytzes (Ioannes Kamytzes).