Marbofloxacin

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Marbofloxacin
Marbofloxacin.PNG
Systematic (IUPAC) name
9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol(3,2,1-ij)(4,2,1)benzoxadiazin-6 carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status veterinary prescription only
Routes oral
Identifiers
CAS number 115550-35-1 N
ATCvet code QJ01MA93
ChemSpider 54663 YesY
UNII 8X09WU898T YesY
ChEMBL CHEMBL478120 YesY
Chemical data
Formula C17H19FN4O4 
Mol. mass 362.356
 N (what is this?)  (verify)

Marbofloxacin is a carboxylic acid derivative third generation fluoroquinolone antibiotic. It is used in veterinary medicine under the trade names Marbocyl,Forcyl and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon (CAS number 115550-35-1).

Mechanism of action[edit]

Its mechanism of action is not thoroughly understood, but it is believed to be similar to the other fluoroquinolones by impairing the bacterial DNA gyrase which results in rapid bactericidal activity.[1] The other proposed mechanisms include that it acts against nondividing bacteria and does not require protein and RNA synthesis, which block protein and RNA synthesis respectively.[2]

Activity[edit]

Marbofloxacin is a synthetic, broad spectrum bactericidal agent. The bactericidal activity of marbofloxacin is concentration dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. Like other fluoroquinolones, marbofloxacin has demonstrated a significant post-antibiotic effect for both gram–and + bacteria and is active in both stationary and growth phases of bacterial replication.[3]

It has good activity against many gram-negative bacilli and cocci, is effective against:

Pseudomonas aeruginosa 

Klebsiella spp

Escherichia coli

Enterobacter

Campylobacter

Shigella

Salmonella

Aeromonas

Haemophilus

Proteus

Yersinia

Serratia

Vibrio

Brucella

Chlamydia trachomatis

Staphylococci (including penicillinase-producing and methicillin-resistant strains)

Mycoplasma

Mycobacterium

Application[edit]

Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection.[4] Maximum duration of treatment is 30 days.[3]

Contraindications and side effects[edit]

Marbofloxacin should usually be avoided in young animals because of potential cartilage abnormalities. In rare occasion, it can cause CNS stimulation and should be used with caution in patients with seizure disorders.[3] Under certain conditions it can cause discomfort such as cramps, treatable with diazepam. Other adverse effects are usually limited to GI distress (vomiting, anorexia, soft stools, diarrhoea) and decreased activity.[3]

See also[edit]

References[edit]

  1. ^ Boothe, D.M. (2001) Antimicrobial drugs. In Small Animal ClinicalPharmacology and Therapeutics, pp. 150–173. W. B. Saunders Co.,Philadelphia, PA.
  2. ^ Hunter RP, Koch DE, Coke RL, Carpenter JW, Isaza R. Identification and comparison of marbofloxacin metabolites from the plasma of ball pythons (Python regius) and blue and gold macaws (Ara ararauna). J Vet Pharmacol Ther. 2007 Jun;30(3):257-62.
  3. ^ a b c d Plumb DC (ed). Plumb's Veterinary Handbook, 7th ed. Ames, IA: Wiley-Blackwell Publishing, 2011.
  4. ^ Rougier S, Borell D, Pheulpin S, Woehrlé F, Boisramé B (October 2005). "A comparative study of two antimicrobial/anti-inflammatory formulations in the treatment of canine otitis externa". Vet. Dermatol. 16 (5): 299–307. doi:10.1111/j.1365-3164.2005.00465.x. PMID 16238809. 

External links[edit]