It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI scan. If Marburg disease occurs in the form of a single large lesion, it can be radiologically indistinguishable from a brain tumor or abscess. In such cases, craniotomy and biopsy are needed to exclude other pathologies. It is usually lethal, but it has been found to be responsive to Mitoxantrone and Alemtuzumab, and it has also been responsive to autologous stem cell transplantation. Recent evidence shows that Marburg's presents a heterogeneous response to medication, as does standard MS.
Marburg variant of MS is an acute fulminant demyelinating process which in most cases progresses inexorably to death within 1–2 years. However, threre are some reports of Marburg MS reaching stability by three years.
^Fontaine B (2001). "Borderline forms of multiple sclerosis". Rev. Neurol. (Paris) (in French) 157 (8–9 Pt 2): 929–34. PMID11787357.
^Lublin FD, Reingold SC (April 1996). "Defining the clinical course of multiple sclerosis: Results of an international survey". Neurology46 (4): 907–11. doi:10.1212/WNL.46.4.907. PMID8780061.
^Capello E, Mancardi GL (November 2004). "Marburg type and Balò's concentric sclerosis: rare and acute variants of multiple sclerosis". Neurol. Sci.25 (Suppl): S361–3. doi:10.1007/s10072-004-0341-1. PMID15727234.
^Kimiskidis VK, Sakellari I, Tsimourtou V et al. (2007). "Autologous stem cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome". Multiple Sclerosis14 (2): 278–83. doi:10.1177/1352458507082604. PMID17942513.CS1 maint: Explicit use of et al. (link)
^Leussink VI, Lehmann HC, Meyer Zu Hörste G, Hartung HP, Stüve O, Kieseier BC. (2008). "Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab: Evidence for disease heterogeneity". Journal of Neurology255 (9): 1436–8. doi:10.1007/s00415-008-0956-x. PMID18685916.
^Dan L. Longo, et.al, ed. (2012). Harrison's principles of internal medicine. (18th ed.). New York: McGraw-Hill. p. 3407. ISBN9780071748896.
^Turatti, M; Gajofatto, A; Rossi, F; Vedovello, M; Benedetti, MD (Dec 2010). "Long survival and clinical stability in Marburg's variant multiple sclerosis.". Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology31 (6): 807–11. doi:10.1007/s10072-010-0287-4. PMID20461429.