It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI scan. If Marburg Disease occurs in the form of a single large lesion, it can be radialogically indistinguishable from a brain tumor or abscess. In such cases, craniotomy and biopsy is needed to exclude other pathologies. It is usually lethal, but it has been found to be responsive to Mitoxantrone and Alemtuzumab, and it has also been responsive to autologous stem cell transplantation. Recently it has been shown that it presents a heterogeneous response to medication, as does standard MS.
Marburg variant of MS is an acute fulminant demyelinating process which in most cases progresses inexorably to death within 1–2 years. However, threre are some reports of Marburg MS reaching stability by 3 years and hence there is some possibly of lng survival and clinical stability in such patients.
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