He is a singer, songwriter (words and music), and guitarist, who has performed with Céline Dion on tour and on other occasions. She appears in the music video for Marc Dupré's single "Tout près du bonheur", which was filmed "in early May 2006 in the Nevada desert". According to "What's Goin' On", posted on the official website of Céline Dion, "Céline composed the music for this song a few years ago when Marc Dupré married her husband René's daughter Anne-Marie. The concept of the music video is also based on an idea that Céline proposed." The song "Tout près du bonheur" is included on Marc Dupré's first album Refaire le monde. In 2013 he is one of the four judges in the Quebec version of The Voice "La Voix".
At the first Gala Artis, held in Montreal on Sunday, April 30, 2006, Céline Dion also performed "Tout près du bonheur" (in French only) with Marc Dupré.