Marchiafava–Bignami disease

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Marchiafava–Bignami disease
Classification and external resources
ICD-10 G37.1
ICD-9 341.8
DiseasesDB 31494
eMedicine neuro/204
MeSH D054319

Marchiafava–Bignami disease is a progressive neurological disease of alcoholism, characterized by corpus callosum demyelination and necrosis and subsequent atrophy.

Eponym[edit]

It was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker.[1][2] In this patient, Marchiafava and Bignami noticed that the middle two-thirds of the corpus callosum were necrotic.

Causes[edit]

It is classically associated with chronic alcoholism and sometimes associated nutritional deficiencies.[citation needed]

See also[edit]

References[edit]

  1. ^ synd/2922 at Who Named It?
  2. ^ E. Marchiafava, A. Bignami. Sopra un' alterazione del corpo calloso osservata da sogetti alcoolisti. Rivista di patologia nervosa e mentale, 1903, 8 (12): 544–549.

External links[edit]