Marco was born in the Wilhelmina Hospital in Alkmaar as the son of Roberto Borsato and Mary de Graaf. He has a brother, Armando, and a sister, Sylvana. The family moved to Italy, where the father started up a restaurant in Garda. Marco spent a significant amount of time in Italy and speaks fluent Italian.
When Marco was 12 years old he decided he wanted to be a sushi chef. Marco, though brought up with Italian cuisine, felt a great love for this cuisine. When he was older he went to school during the week and worked in a restaurant during the weekends. During his conscription he was bound to the cavalery, where he was conscripted as a NCO. Success did not come over night after winning the Dutch Soundmixshow on April 6, 1990 with his rendition of Billy Vera's "At This Moment." During that time he was indeed working as a chef.
Marco released 3 albums with Italian songs, before gaining popularity in 1994 with his first Dutch single "Dromen Zijn Bedrog" ("Dreams will deceive") which reached number one and stayed there for 12 weeks. His second single "Waarom Nou Jij" also reached the first place in the Dutch "Top 40." 
Many of his songs are Dutch covers or adaptations of Italian songs (by Riccardo Fogli, Giorgia, Riccardo Cocciante, Claudio Baglioni, Marco Masini and Zucchero among others). In particular, Borsato gained a lot of success in 1996 with an adaptation of Riccardo Cocciante's Margherita. After deciding to keep singing in dutch, Borsato's career really took off. He has consistently been one of the most succesful and biggest grossing artists in the Netherlands for the past twenty years.
In 2009 Marco was dealt a financial blow when his company The Entertainment Group, a major events organiser and dutch artists representer, was declared bankrupt by a dutch court.
In 2011 he became a judge on the dutch talent show The Voice of Holland.
Marco married dutch tv personality Leontine Ruiters and they have 3 children together: Luca (1998), Senna (2001), and Jada (2002).