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Maresins are newly described macrophage-derived mediators of inflammation resolution. The term Maresins is coined from Macrophage mediator in resolving inflammation (maresin), they were found to possess potent anti-inflammatory and proresolving properties similar to Resolvin E1.
Addition of either the essential fatty acid, docosahexaenoic acid (DHA) to activated macrophages converted these substrates into Maresins. Maresin 1, MaR1, proved to be a potent mediator, stopping PMN infiltration and stimulating macrophage phagocytosis of apoptotic cells, Efferocytosis. An isomer of MaR1,was less potent, indicating stereoselective actions in vitro and in vivo.