He had two sons and one daughter: Quincy Howe (1900-1977), news analyst and author, Helen Huntington Howe (1905-1975), monologuist and novelist who married Reginald Allen, and Mark De Wolfe Howe (1906-1967), Harvard law professor, historian, biographer, civil rights leader.
He served as associate editor of the Youth's Companion from 1888 to 1893 and again from 1899 to 1913, as assistant editor of the Atlantic Monthly in 1893-1895, and as editor of the Harvard Alumni Bulletin until 1913. He was also Vice President of the Atlantic Monthly company from 1911 to 1929. As an author he won the Pulitzer Prize for Biography or Autobiography for Barrett Wendell and His Letters. He was the editor of Harvard Volunteers in Europe in 1916.
Besides editing The Memory of Lincoln (1889), Home Letters of General Sherman (1909), The Beacon Biographies (31 volumes, 1899–1910), and Lines of Battle and Other Poems by Henry Howard Brownell (1912), he published the following: