Lewis amassed 48 home runs, 306 RBI and a .263 batting average over 902 games of major league play. A large majority of his home runs came between 1996 and 1999. During those four years he hit 36 home runs (9 per year). He did not hit a single home run as a rookie for the Indians in more than 300 at bats. His career highlight may have occurred in Game 3 of the 1995 National League Division Series when as a member of the Cincinnati Reds, playing against the Los Angeles Dodgers, he hit the first pinch-hit grand slam in postseason history.
After the 2001 season, Lewis became a free agent, ending his major league career at the age of 31. He briefly attempted a comeback in 2007 with the Long Island Ducks, but it lasted just one game.