Matrix metallopeptidase 12

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macrophage elastase
Identifiers
EC number 3.4.24.65
CAS number 146888-86-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Matrix metallopeptidase 12 (macrophage elastase)
Protein MMP12 PDB 1jiz.png
PDB rendering based on 1jiz.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MMP12 ; HME; ME; MME; MMP-12
External IDs OMIM601046 MGI97005 HomoloGene20547 ChEMBL: 4393 GeneCards: MMP12 Gene
EC number 3.4.24.65
RNA expression pattern
PBB GE MMP12 204580 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4321 17381
Ensembl ENSG00000110347 ENSMUSG00000049723
UniProt P39900 P34960
RefSeq (mRNA) NM_002426 NM_008605
RefSeq (protein) NP_002417 NP_032631
Location (UCSC) Chr 11:
102.73 – 102.75 Mb
Chr 9:
7.34 – 7.37 Mb
PubMed search [1] [2]

Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene.[1][2][3]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins. The prodomain is cleaved by extracellular proteinases when the enzyme is activated. The active enzyme is constituted by two domains, the catalytic domain resposnsible for its enzymatic activity and the hemopexin-like domain that in some MMPs plays a role in substrate recognition and can contribute to increasing catalytic efficiency. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[1]

Clinical significance[edit]

MMP12 may play a role in aneurysm formation[4] and studies in mice and humans suggest a role in the development of emphysema.[5]

References[edit]

  1. ^ a b "Entrez Gene: MMP12 matrix metallopeptidase 12 (macrophage elastase)". 
  2. ^ Shapiro SD, Kobayashi DK, Ley TJ (November 1993). "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". J. Biol. Chem. 268 (32): 23824–9. PMID 8226919. 
  3. ^ Belaaouaj A, Shipley JM, Kobayashi DK, Zimonjic DB, Popescu N, Silverman GA, Shapiro SD (June 1995). "Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression". J. Biol. Chem. 270 (24): 14568–75. doi:10.1074/jbc.270.24.14568. PMID 7782320. 
  4. ^ Curci JA, Liao S, Huffman MD, Shapiro SD, Thompson RW (December 1998). "Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms". J. Clin. Invest. 102 (11): 1900–10. doi:10.1172/JCI2182. PMC 509141. PMID 9835614. 
  5. ^ Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ (December 2005). "A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking". Am. J. Respir. Crit. Care Med. 172 (11): 1383–92. doi:10.1164/rccm.200505-686OC. PMC 2718436. PMID 16166618. 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.009