Matrix metalloproteinase inhibitor

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A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous.

The most notorious endogenous metalloproteinases are tissue inhibitor of metalloproteinases (TIMP). There are also cartilage-derived angiogenesis inhibitor‎s.

Exogenous matrix metalloproteinase inhibitors include batimastat and marimastat.

This biochemistry article is a stub. You can help Wikipedia by expanding it.

Pharmacology: enzyme inhibition

Class

Competitive inhibition · Uncompetitive inhibition · Non-competitive inhibition · Suicide inhibition · Mixed inhibition

Substrate

Oxidoreductase (EC 1)	1.1 Aldose reductase · HMG-CoA reductase 1.3 5-alpha-reductase 1.4 Monoamine oxidase 1.5 Dihydrofolate reductase 1.13 Lipoxygenase 1.14 Aromatase · COX-2 1.17 Xanthine oxidase · Ribonucleotide reductase

Transferase (EC 2)	2.1 COMT · Thymidylate synthase 2.4 PARP 2.5 Dihydropteroate synthetase · Farnesyltransferase 2.6 GABA transaminase 2.7 Nucleotidyltransferase (Integrase, Reverse transcriptase) · Protein kinase (Tyrosine-kinase (Janus kinase))

Hydrolase (EC 3)	3.1 Phosphodiesterase · Acetylcholinesterase · Ribonuclease 3.2 Polygalacturonase · Neuraminidase · Alpha-glucosidase 3.4 Protease: Exopeptidase (Dipeptidyl peptidase-4, ACE) · Endopeptidase (Trypsin, Renin, Matrix metalloproteinase) 3.5 Histone deacetylase · Beta-lactamase

Lyase (EC 4)	4.1 Dopa decarboxylase 4.2 Carbonic anhydrase

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