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A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs). There are also cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors that were developed as anticancer drugs include batimastat and marimastat.
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalapods, mollusks, algea and bacteria.
- ^ Noel Vinay Thomas, Se Kwon Kim (2010). "Metalloproteinase Inhibitors Stts and Scope from Marine Organisms". Biochemistry Research International.