Mangini started the 2011 season on the disabled list and was activated on April 21, but was immediately optioned to Triple-A. He was released on August 23, after leaving Triple-A Tacoma for an undisclosed personal issue.
The Tampa Bay Rays signed Mangini to a minor league contract on December 6, 2011. He also received an invitation to spring training. The Arizona Diamondbacks signed Mangini to a minor league contract on August 14, 2012. He signed a minor league contract with the Cincinnati Reds on February 2, 2013. He was released on March 27.