Maytansine

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Maytansine
Maytansine structure.svg
Identifiers
CAS number 35846-53-8 YesY
PubChem 5281828
UNII 14083FR882 N
ChEBI CHEBI:6701 N
ChEMBL CHEMBL488931 N
Jmol-3D images Image 1
Properties
Molecular formula C34H46ClN3O10
Molar mass 692.20 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Maytansine (USAN), or maitansine (INN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.[1]

It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus.[1]

Derivatives are known as maytansinoids.[2]

See also[edit]

References[edit]

  1. ^ a b National Cancer Institute: Definition of Maytansine
  2. ^ Yu, T.-W.; Bai, L; Clade, D; Hoffmann, D; Toelzer, S; Trinh, KQ; Xu, J; Moss, SJ; Leistner, E (2002). "The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnemapretiosum". Proceedings of the National Academy of Sciences 99 (12): 7968–7973. doi:10.1073/pnas.092697199. PMC 123004. PMID 12060743.