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McGuffin is a surname of Scottish origin. Notable people with the surname include:

  • David McGuffin, Canadian television correspondent
  • Peter McGuffin, Northern Irish geneticist
  • Samuel McGuffin (1863–1952), Northern Ireland politician
  • John McGuffin (1942–2002), Civil Rights Activist, Political Activist, Author: "The Guineapigs", "In Praise of Poteen", "The Hairs of the Dog" and "Last Orders, Please!".

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