The quiet community of Meadowview was called Meadow View (two separate words) until the 1930s. Native American trails passed near the later site of the town. The first settler was James Glenn, who purchased land in 1783. Different theories exist regarding the origin of community's name. Some believe the name may come from an early name of Meadow Mountain, the name for nearby Whitetop Mountain on the 1749 Peter Jefferson Map. Another explanation is that William Edmondson named his house Edmondson's Meadow and enjoyed looking at the numerous green meadows surrounding his house. Until the railroad's arrival in 1856, the town was small and remote. After the train arrived, stockyards and a transportation center were established in Meadowview to ship livestock, produce and goods to all over the eastern US. The town remained busy and active until the 1950s, when the departure of the train hurt the economy. The area is now mainly a residential community.