Mederma

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Mederma is a topical product used to improve scar appearance. It is a gel based on an onion extract and produced by Merz Pharmaceuticals[1] of Frankfurt, Germany. Mederma's marketing claims it can make scars "softer, smoother, and less noticeable".[2] Generic versions are sold under the name Cepalin.

Effectiveness[edit]

One 2006 clinical trial found no statistically significant change in hypertrophic scar appearance from products of this type compared to the standard petrolatum emollient,[3] while a 1999 pilot trial found an onion extract gel less effective than the petrolatum.[4] In 2010 a 54-person trial funded by Merz found that an onion extract cream improved the appearance of stretch marks.[5]

Basic research and animal testing suggest the gel could be effective. A 1996 study into the therapeutic values of onion and garlic found that they may act as an anti-inflammatory and bacteriostatic[6] and in 2002, researchers found that Mederma improved collagen organization after injury in rabbits.[7]

Active ingredient[edit]

Allium cepa, the common onion, is the active content of Mederma.[7] Onions contain a readily available[8] and highly researched bioflavonoid with antihistamine and antiproliferative effects on both normal and malignant cells.

Full ingredients[edit]

Water (purified), PEG-4, Aloe barbadensis leaf juice, Allium cepa (onion) bulb extract, xanthan gum, allantoin, methylparaben, sorbic acid, fragrance.[9]

Similar product[edit]

Merz Pharmaceuticals also produces Contractubex for scars, which also contains onion extract in addition to other ingredients. Contractubex has reportedly been found effective in clinical trials.[10]

References[edit]

  1. ^ MEDERMA Skin Care for SCARS
  2. ^ MEDERMA Skin Care for SCARS Learning Center
  3. ^ Chung VQ, Kelley L, Marra D, Jiang SB (February 2006). "Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study". Dermatol Surg 32 (2): 193–7. doi:10.1111/j.1524-4725.2006.32045.x. PMID 16442038. 
  4. ^ Jackson BA, Shelton AJ (April 1999). "Pilot study evaluating topical onion extract as treatment for postsurgical scars". Dermatol Surg 25 (4): 267–9. doi:10.1046/j.1524-4725.1999.08240.x. PMID 10417579. 
  5. ^ WebMD. Onion Cream Treats New Stretch Marks.
  6. ^ K. Augusti, Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.), Indian J Exp Biol 34 (1996), pp. 634–640.
  7. ^ a b Saulis, Alexandrina S. M.D.; Mogford, Jon H. Ph.D.; Mustoe, Thomas A. M.D. (2002). "Effect of Mederma on Hypertrophic Scarring in the Rabbit Ear Model". Plastic and Reconstructive Surgery 110 (1): 177–183. doi:10.1097/00006534-200207000-00029. PMID 12087249. 
  8. ^ quercetin - Google Product Search
  9. ^ Mederma Gel patient advice, including possible side effects
  10. ^ Ho WS, Ying SY, Chan PC, Chan HH (July 2006). "Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial eczema". Dermatol Surg 32 (7): 891–6. doi:10.1111/j.1524-4725.2006.32192.x. PMID 16875470.