Medial forebrain bundle
|Medial forebrain bundle|
|Latin||fasciculus medialis telencephali|
|NeuroLex ID||Medial forebrain bundle|
|Anatomical terms of neuroanatomy|
The medial forebrain bundle (MFB), is a tract containing fibres from the basal olfactory regions, the periamygdaloid region and the septal nuclei, as well as fibres from brainstem regions, including the ventral tegmental area.
The MFB passes through the lateral hypothalamus. It contains both ascending and descending fibres. It also represents a part of the mesolimbic pathway, carrying information between the ventral tegmentum and the nucleus accumbens.
Electrical stimulation of the medial forebrain bundle is believed to cause sensations of pleasure. This hypothesis is based upon intracranial self-stimulation (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable. It is possible that the medial forebrain bundle carries some of the input from the ventral tegmental area (VTA) to the nucleus accumbens (NAcc or Acb). The NAcc is a recognized reward center, and activation of the pathway from the VTA to the NAcc is believed to be rewarding, which is why it is sometimes referred to as the hedonic highway. The MFB also contains serotonergic and noradrenergic fibres.
- Hernandez G, Hamdani S, Rajabi H, et al. (August 2006). "Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences". Behav. Neurosci. 120 (4): 888–904. doi:10.1037/0735-7044.120.4.888. PMID 16893295.
- The Owner's Manual for the Brain: Everyday Applications from Mind-Brain Research, 3rd ed. 2006. Austin: Bard Press. ISBN 1-885167-64-4
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