"Medicine" is the first promo single of American hip hop rapper Plies' fourth studio album, Goon Affiliated. The track is absent from the retail versions for unknown reasons, but is on the Amazon deluxe version. The track features American singer-songwriter Keri Hilson. There are two versions, one with a more radio friendly, slow beat and one with a more club beat.
A music video was shot for the song and premiered on January 14, 2010. It takes place in a hospital where Keri Hilson plays a nurse and Plies is the doctor which makes reference to the song. Myammee from VH1 also makes a cameo in the beginning of the video.