Medroxyprogesterone
| Medroxyprogesterone | |
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17-acetyl-17-hydroxy- 6,10,13-trimethyl- 1,2,6,7,8,9,10,11,12,13,14,15,16,17- tetradecahydrocyclopenta[a]phenanthren-3-one |
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| Identifiers | |
| CAS number | 520-85-4  |
| PubChem | 10631 |
| ChemSpider | 10185 |
| UNII | HSU1C9YRES |
| DrugBank | DB00603 |
| KEGG | D08166 |
| ChEBI | CHEBI:6715 |
| ChEMBL | CHEMBL279067  |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C22H32O3 |
| Molar mass | 344.488 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Medroxyprogesterone (MP) is a pregnane that acts as a progestin. An acylated derivative, medroxyprogesterone 17-acetate (MPA) is clinically used as a drug.[1] Compared to MPA, MP is approximately 100 fold less potent as a progestin.[2] MP is also a metabolite of MPA.[3]
While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone 17-acetate,[1] what is normally being administered is medroxyprogesterone 17-acetate and not medroxyprogesterone.[4]
Medroxyprogesterone is used to regulate irregular periods in a woman's menstral cycle. This drug is also used with women going through menopause.
It can be used by male to female transsexuals.
[edit] See also
[edit] References
- ^ a b "MedroxyPROGESTERone: Drug Information Provided by Lexi-Comp". Merck Manual. 2009-12-01. http://www.merck.com/mmpe/lexicomp/medroxyprogesterone.html. Retrieved 2010-07-08.
- ^ Pullen MA, Laping N, Edwards R, Bray J (September 2006). "Determination of conformational changes in the progesterone receptor using ELISA-like assays". Steroids 71 (9): 792–8. doi:10.1016/j.steroids.2006.05.009. PMID 16784762.
- ^ Ishihara M, Kirdani Y, Osawa Y, Sandberg AA (January 1976). "The metabolic fate of medroxyprogesterone acetate in the baboon". J. Steroid Biochem. 7 (1): 65–70. doi:10.1016/0022-4731(76)90167-9. PMID 1271819.
- ^ Lenco W, Mcknight M, Macdonald AS (January 1975). "Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits". Ann. Surg. 181 (1): 67–73. doi:10.1097/00000658-197501000-00015. PMC 1343717. PMID 1119869. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1343717.
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