Reviews for the album were mostly positive. Unlike her debut, Meet the Girl Next Door was given 4/5 stars by Andy Kellman of AllMusic, who described Mo's voice more "rangy" and "versatile". He also stated that the album had terrific highlights, as well as more better lyrics than her debut. However, he described the album being, "four songs too long." He also stated that, "... it's apparent that Lil' Mo really ought to devote the bulk of her working time — if not all of it — to making music."
Upon its release, Meet the Girl Next Door debuted on the Billboard 200 at number 17 and peaked at number 4 on the Top R&B/Hip-Hop Albums. To date, it remained her highest-charting album on the latter chart. The album sold an estimate of 110,000 copies within its first week, and went on to sell 250,000 more towards the end of the year.
In February 2003, "4Ever", featuring Fabolous, was released as a lead single for the album, and received somewhat lukewarm reviews by most critics. The song peaked at number 37 on Billboard Hot 100 and at number 13 on Hot R&B/Hip-Hop Songs. "Ten Commandments", featuring Lil' Kim, was slated to follow as the second single; however, due to limited promotion, and failed attempts for a video, the single was never properly released. "21 Answers" (a known response to 50 Cent's "21 Questions") was sent to radio in May 2003 as a promotional single. Because it did not finalize in time to meet the album's deadline, it never appeared on the original tracklisting. Because of lack of promotion for the album, as well as no new singles to be released, Mo left Elektra Records in 2004.