The Chris Cox-produced megamix contains thirteen of Jackson's past singles, and was released prior to the lead single from 2004's Damita Jo, "Just a Little While". During the production of the remix, Cox's studio in California was ravaged by a wildfire, and the DJ had to evacuate it midway through the project. The single entered the BillboardHot Dance Club Play chart at number thirty-four and charted for eleven weeks, peaking at number three in early March 2004.
The single was released in several international territories but was not eligible for mainstream charts as it was not released commercially. The only version available on a commercial format is the Chris Cox Radio Edit which appears as a B-side to the UKCD single of "Just a Little While".
A music video for "Janet Megamix 04" was produced using the radio edit version of the track and consists of a montage of footage from Jackson's other videos used in the single. The video has never been released commercially, but can be found on YouTube.