Mehytenweskhet was the daughter of the High Priest of Re Harsiese. It has been suggested that the high priest Harsiese is identical to the Vizier Harsiese who may have served Taharqa. If so, Harsiese would have served as vizier to Taharqa, while opening up relations with Necho I while the latter was ruler of Sais. This may have allowed Harsiese to remain in office as vizier into the reign of his son-in-law Psamtik I. If the Vizier Harsiese was Mehytenweskhet's father, she would have been a sister of Naneferhenes, who was married to a Theban priest named Nesamun.