In October 1963, the Mel’s Drive-In chain was picketed and subjected to a sit-in by the Ad Hoc Committee to End Discrimination over the fact that while the restaurant would serve food to African Americans and hired them as cooks, they were not allowed to work "up front" where they could be seen by white customers. More than 100 protesters were arrested. The picketing ended when Harold Dobbs, a San Francisco City Supervisor who had run for Mayor and lost, settled with the protesters and began to allow black workers "up front." 
Mel’s was used as a location in the 1967 film Guess Who’s Coming to Dinner. Spencer Tracy and Katharine Hepburn are out for a drive and Tracy pulls into Mel’s and orders Oregon Boysenberry ice cream, then has a minor traffic altercation with a black man. The Mel’s was located in the Excelsior district of San Francisco. Katharine Hepburn and Spencer Tracy never actually visited the location.
In 1972, the restaurant was selected as a feature location by George Lucas for his 1973 film American Graffiti. The prominent play given to the location has been credited with having saved the company from possibly going out of business. The Mels used was located at 140 South Van Ness in San Francisco.
Some Mel’s Drive-In locations are not actually drive-ins, but rather diners, although the sign still says "drive-in"; none of the San Francisco locations serve food to patrons’ cars.
Mel’s Drive-in vs. “Mel’s Original”
Universal Studios built a replica of “Mel’s Drive-In” on its lot, pursuant to the restaurant being used in American Graffiti – this amusement attraction also served as a gift shop for years. There are also a number of “Mel’s” located in Northern California that share the same general American Graffiti nostalgia theme and the similarly styled Mel’s logo. These restaurants are called “Mel’s Original”. Their locations are not listed on the official Mel’s Drive-In website, although an article from the Sacramento Business Journal shows that they are related. A family rift caused the Weisses to part ways and form two chains. The elder Weiss in 1994 sold his company to Larry Spergel, who formed a group of about 50 stockholders that now owns the chain. The Walnut Creek, California, location features a history of the original San Francisco Mels.
Signage and menus on the original Mel’s Diners did not have a possessive apostrophe in the name, as would be expected. However, when Universal Studios recreated the diners at their theme parks in Hollywood, Orlando, Singapore, and Japan, they opted to include the apostrophe in all "Mel's Drive-In" signage, literature, and media.
- Mels Original official website
- Mels Drive-In official website
- Original Mels and Mels Drive-in Article
- Mel's Drive-in: The True Story of the World's Most Famous Drive-in Pt.1 Article