Melanocortin 5 receptor

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Melanocortin 5 receptor
Symbols MC5R ; MC2
External IDs OMIM600042 MGI99420 HomoloGene4321 IUPHAR: MC5 ChEMBL: 4608 GeneCards: MC5R Gene
RNA expression pattern
PBB GE MC5R 208565 at tn.png
More reference expression data
Species Human Mouse
Entrez 4161 17203
Ensembl ENSG00000176136 ENSMUSG00000007480
UniProt P33032 G3UWB6
RefSeq (mRNA) NM_005913 NM_013596
RefSeq (protein) NP_005904 NP_038624
Location (UCSC) Chr 18:
13.82 – 13.83 Mb
Chr 18:
68.34 – 68.34 Mb
PubMed search [1] [2]

Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene.[1][2] It is located on the chromosome 18 in the human genome.[2] When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[3]

See also[edit]


  1. ^ Chhajlani V, Muceniece R, Wikberg JE (Oct 1993). "Molecular cloning of a novel human melanocortin receptor". Biochem Biophys Res Commun 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929. 
  2. ^ a b "Entrez Gene: MC5R melanocortin 5 receptor". 
  3. ^ Thiboutot, Diane; Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary (2000). "The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells". Journal of Investigative Dermatology 115 (4): 614–619. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132. Retrieved 2008-01-04. 

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Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.